Adding a certain compound to certain chemical reactions, such as: 162102-79-6, Dimethyl 4-bromopyridine-2,6-dicarboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H8BrNO4, blongs to pyridine-derivatives compound. Computed Properties of C9H8BrNO4
In a sealed tube, a mixture of 1 (2.74 g, 10 mmol)and (S)-phenylalaninol (3.78 g, 25 mmol) in methanol (10 mL) was stirred at 115 C for 12 h. After cooling to ambient temperature, the crude product was poured into crushed ice (100 g), stirred for15 min, filtered, washed with water (20 mL 3) and the residues was dried under vacuum. The white product was used for the next step without further purification (4.50 g, 88%). 1H NMR (400 MHz,CDCl3): d 8.43 (s, 2 H), 7.94 (d, J 8 Hz, 2 H), 7.32e7.21 (m, 10 H),4.40e4.32 (m, 2 H), 3.83e3.74 (m, 4 H), 3.06e2.96 (m, 4 H), 2.59 (br,2 H). 13C NMR (150 MHz, CDCl3): d 162.6, 149.7, 137.5, 136.4, 129.4,128.8, 128.5, 126.9, 63.6, 53.1, 37.0. HRMS (MALDITOF) calcd forC25H27BrN3O4 [M H] 512.1179, found 512.1186.
The synthetic route of 162102-79-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Ya-Qi; Pan, Yao; Gao, Wan-Qing; Wu, Yuan; Liu, Chun-Hua; Zhu, Yuan-Yuan; Tetrahedron; vol. 75; 28; (2019); p. 3809 – 3814;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem