As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50720-12-2, name is 3-Bromo-5-methoxypyridine, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives
A solution of 3-bromo-5-methoxy-pyridine (33 18.8 g, 0.1 mol), HBr (80 mL, 48%) and glacial HOAc (60 mL) was stirred overnight at 120 C. Hydrobromic acid (60 mL, 48%) was added slowly to replace evaporated solvents and stirred at 120 C. for overnight. The reaction mixture was cooled to RT and then poured into the ice. The pH was adjusted to about 6 by adding 6N NaOH and then extracted with EtOAc (2×200 mL). The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude product was stirred in CH2Cl2 (150 mL) and the resulting precipitate was filtered. The product was washed with CH2Cl2 to afford 3-bromo-5-hydoxypyridine (34; 15.2 g, 87.4% theory) as a white solid.
With the rapid development of chemical substances, we look forward to future research findings about 50720-12-2.
Reference:
Patent; Roche Palo Alto LLC; US2005/234236; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem