Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 685517-71-9, name is 2,6-Difluoro-4-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H2F2IN
To a solution of 4-(5-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)thiazole (300 mg, 1.29 mmol) in DMSO (5 mL) was added 2,6-difluoro-4-iodopyridine (373 mg, 1.55 mmol) and NaHC03 (542 mg, 6.45 mmol) and the resulting mixture was stirred for 18 hrs at 80 C. After being cooled to rt, the resulting reaction mixture was filtered and the filtrate was diluted with brine and extracted in DCM (30 mL) for three times. The combined organic layer was dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by column chromatography (eluting with DCM/MeOH=20/l, v:v) to give 4-[6-(6-fluoro-4-iodo-2-pyridyl)- 5-methyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]thiazole (520 mg) as yellow solid.
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; HAN, Xingchun; WANG, Yongguang; YANG, Song; (84 pag.)WO2018/83081; (2018); A1;,
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