Reference of 10128-71-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10128-71-9, name is 3-Hydroxyisonicotinic acid, molecular formula is C6H5NO3, molecular weight is 139.11, as common compound, the synthetic route is as follows.
Acetyl chloride (20 mE) was added dropwise to methanol (200 mE) at 00 C. After the addition, the reaction mixture was stirred at this temp for 15 mm and then 4.0 g of the acid was added. The reaction mixture was heated at reflux for 12 h. Methanol was removed to give a residue, which was then carefully neutralized with aq. sat. NaRCO3 and then extracted with EtOAc (3x). The organic layers were combined, dried and evaporated to give the ester as a yellow solid, which was used in the next step without further purification.
Statistics shows that 10128-71-9 is playing an increasingly important role. we look forward to future research findings about 3-Hydroxyisonicotinic acid.
Reference:
Patent; Global Blood Therapeutics, Inc.; The Regents of the University of Califorina; Cytokinetics, Inc.; Metcalf, Brian; Chuang, Chihyuan; Warrington, Jeffrey; Paulvannan, Kumar; Jacobson, Matthew P.; Hua, Lan; Morgan, Bradley; US2015/344483; (2015); A1;,
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