Synthetic Route of 7251-52-7 ,Some common heterocyclic compound, 7251-52-7, molecular formula is C13H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
d) (RS)-Phenyl-pyridin-2-yl-acetamide (0.340 g, 1.60 mmol) was dissolved in 5 ml of a saturated solution of HCl/methanol and refluxed for 6 h in a closed vessel. The mixture is poured on 25 g of ice, the pH is adjusted to 8-9 by cautious addition of 28% sodium hydroxide solution keeping the temperature below 10 C. and the product is extracted with ethyl acetate/water. After drying (MgSO4) and concentration, the crude material is purified by flash chromatography on silicagel using 1:4 mixture of ethyl acetate and hexane as eluant to yield 0.204 g (0.939 mmol, 59%) of (RS)-phenyl-pyridin-2-yl-acetic acid methyl ester as a white solid, m.p. 74 C. and MS: m/e=228.2 (M+H+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7251-52-7, its application will become more common.
Reference:
Patent; Hoffmann-La Roche Inc.; US6548522; (2003); B1;,
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