Related Products of 138487-20-4 ,Some common heterocyclic compound, 138487-20-4, molecular formula is C9H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 4-(3-pyridyl)-but-3-yn-1-ol (0.32 g, 2.2 mmol) in EtOH (44 mL) was passed through the H-Cube hydrogenator flow reactor provided with a 10% Pd/C cartridge (flow rate: 1.0 mL/min; P = 1.0 bar; T = 3 5C). The outcoming solution was concentrated to dryness giving an oily residue (0.31 g). Purification by typical silica gel flash chromatography(CH2C12/MeOH, 95:5), afforded the pure title compound (0.294 g, 89%), as a colorless liquid. R = 1.16 mm. MS (ESI) m/z: 152 [M-H]. ?H NMR (DMSO-d6): oe 8.43 (m, 1H), 8.38 (dd, 1H, J= 4.8, 1.5 Hz), 7.61 (dt, 1H, J= 7.8, 2.1 Hz), 7.30 (dd, 1H, J= 7.8, 4.8 Hz), 4.37 (t, 1H, J= 5.2 Hz), 3.41 (q, 2H, J= 5.2 Hz), 2.59 (t, 2H, J= 7.7 Hz), 1.64-1.55 (m, 2H), 1.47-1.38 (m, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,138487-20-4, its application will become more common.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; PIOMELLI, Daniele; BANDIERA, Tiziano; BERTOZZI, Fabio; NUZZI, Andrea; FIASELLA, Annalisa; PONZANO, Stefano; PAGLIUCA, Chiara; REGGIANI, Angelo Mario; WO2014/144836; (2014); A2;,
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