Electric Literature of 69872-17-9 ,Some common heterocyclic compound, 69872-17-9, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
step 1 : A mixture of 4-bromo-lH-pyrrolo[2,3-c]pyridine (320 mg, 1.62 mmol), Pd(dppf)Cl2 (131 mg, 0.179 mmol), zinc cyanide (190 mg, 1.62 mmol), and zinc powder (21 mg, 0.324 mmol) in DMF (20 mL) was stirred at 120 C for 2 h. The reaction mixtue was cooled to RT andH20 (100 mL) was added. The reaction mixture extracted with EtOAc (3 x 50 mL). The organic layers were concentrated under reduced pressure and the crude residue was purified by S1O2 chromatography eluting with petroleum ether/EtOAc (1 :1) to afford 232 mg (99.8%) of lH-pyrrolo[2,3-c]pyridine-4-carbonitrile as yellow solid: MS (ESI) m/z: 144.2 [M+l] +.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69872-17-9, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy; WO2013/92940; (2013); A1;,
Pyridine – Wikipedia,
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