Electric Literature of 19733-96-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19733-96-1, name is 2-(6-Methylpyridin-3-yl)acetic acid, molecular formula is C8H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 4 Preparation of 2-(6-methylpyridin-3-yl)N-p-tolylamide 2-methylpyridinylacetic acid was dissolved in 150ml of DMF, added with DIEA 40ml, p-toluidine 10.2g, HOBt 18g, and stirred for 15min, then added with EDC.HCl 21g, after addition, the reaction was performed at room temperature for 12h. Then, water 800ml was added for dilution, stirred, insoluble solid appeared, after stirring for 2h, suction filtrated, washed with water to obtain off-white powder solid, dired to obtain 2-(6-methylpyridin-3-yl)N-p-tolylamide 12g, yield was about 68%. 1H-NMR(400MHz,DMSO-d6) delta 2.19(3H,s,CH3); 2.39(3H,s, CH3); 3.56(2H,s, CH2); 7.06-7.04(2H,d, ArH); 7.15-7.17(1H,d, ArH); 7.40-7.42(2H,d, ArH); 7.55-7.57(1H,dd,ArH); 8.32(1H,d,ArH); 10.07(1H,s, NH).
According to the analysis of related databases, 19733-96-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A.; EP2417973; (2012); A1;,
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