Synthetic Route of 139022-27-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 139022-27-8 as follows.
Example 166-fluoro-3-iodo-imidazo^ ,2-alpha]pydine (29)As shown in Fig. 5, 6-Fluoro-3-iodo-imidazo[1 ,2-alpha]pyridine (29) was prepared according to a literature procedure (Enguehard et al., J. Org. Chem. 65: 6572-6575 (2000), incorporated herein by reference in its entirety). N-iodosuccinimide (9.2g, 40.8 mmol) was added to a solution of 6-fluoro-imidazo[1 ,2-alpha]pyridine 26 (Example 15) (7.6g, 40.8 mmol) in dry acetonitrile (100 ml.) at O0C. The reaction was warmed to room temperature and then stirred for 12 hours. The mixture was filtered and the cake washed with acetonitrile and water and dried under high vacuum to afford 6-fluoro-3-iodo-imidazo[1 ,2-alpha]pyridine 29 off white solid. 8.5 g, 88% yield.1H NMR (300 MHz, CDCI3, 297K) delta 7.14 (td, J = 2.1 , 7.8 Hz, 1 H), 7.59 (dd, J = 5.1 , 9.9 Hz, 1 H), 7.72 (s, 1 H), 8.07 (distorted t, J = 3.0 Hz, 1 H).ESI MS (MeOH) calcd for C7H4FIN2 262.03, found m/z (M++1 ) 263.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,139022-27-8, its application will become more common.
Reference:
Patent; ISIS INNOVATION LTD.; EBETINO, Frank, Hallock; MAZUR, Adam; LUNDY, Mark, Walden; RUSSELL, Robert, Graham Goodwin; WO2010/33978; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem