In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42182-27-4, name is 2-Amino-4-cyanopyridine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Amino-4-cyanopyridine
NaN02 (0.99 g, 14.3 mmol) was added in small portions to a well stirred solution of the product of Step B (0.96 g, 8.1 mmol) in a premixed solution of concentrated H2S04 (1 .2 ml) and H20 (1 1 .5 ml) while the temperature of the reaction mixture was kept at ) 0 – 5C. The clear solution became heterogenous with evolution of N2. The mixture was allowed to warm up to room temperature with stirring, than heated on the water bath (reflux) for 30 min and cooled to room temperature. The solid formed was filtered off, washed with H20 and dried in vacuo to give the title product (0.9 g, 92%) as colourless solid. 1 H NMR (DMSO-d6) 8.21 (d, 1 H, J = 2.4 Hz), 7.61 (dd, 1 H, 2.4, 9.6 Hz), 6.38 (d, 1 H, J = 9.6 Hz), 3.3 (broad s, 1 H + 2H20).
The synthetic route of 42182-27-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AKAAL PHARMA PTY LTD; GROBELNY, Damian W; GILL, Gurmit S; WO2014/63199; (2014); A1;,
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