Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 280566-45-2, name is 2-Chloro-6-(trifluoromethyl)nicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives
In a vial, 2-chloro-6-(trifluoromethyl)nicotinic acid (0.98 g, 4.4 mmol) and 2- chloro-6-(trifluoromethyl)isonicotinic acid (1.85 g, 8.2 mmol) were dissolved in ethyl orthoformate (5.0 mL, 30.1 mmol) and heated at 120 C for 5 hours at which time TLC analysis showed that most of the starting material had been consumed and the products were formed. The reaction mixture was evaporated in vacuo and the residue was purified by silica gel chromatography using 10% EtOAc/hexanes to give the two ethyl ester products. ? NMR (400 MHz, CDC13): delta 8.14 (s, 1 H), 8.08 (s, 1 H), 4.47 (q, 2H), 1 .44 (t, 3H).
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Reference:
Patent; INCYTE CORPORATION; RODGERS, James D.; ARVANITIS, Argyrios G.; WO2013/26025; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem