Application of 38186-82-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 38186-82-2, name is 6-Chloro-5-methylpyridin-3-amine. A new synthetic method of this compound is introduced below.
2-Chloro-3-methyl-5-nitro-pyridine (2g, 11.6 mmol) and SnCl2No. (H2O)2 34.8 mmol) are refluxed in MeOH overnight. After cooled down, the mixture is diluted with ethyl acetate, washed with water, brine, dried over MgS04, concentrated and purified by column chromatography to afford 6-chloro-5-methyl-pyridin-3-ylamine (1.7g). To the solution of 6-chloro-5-methyl-pyridin-3-ylamine (1.7g, 11.6 mmol) in IN HCl is added the solution ofNaNOz (960mg, 13.92mmol) in water (10ml) slowly at 0 C. After the addition, the solution is stirred for 20min and then heated to 90 C for 30min. The solution is cooled down, quenched with K2C03, extracted with ether, dried over MgS04, and purified by column chromatography to afford the titled compound (560mg) as a yellow solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,38186-82-2, 6-Chloro-5-methylpyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/123668; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem