Electric Literature of 38186-86-6 ,Some common heterocyclic compound, 38186-86-6, molecular formula is C6H3ClFNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 19 2-Chloro-3-fluoro-5-trifluoromethylpyridine A steel bomb was charged with 6-chloro-5-fluoronicotinic acid (5.4 g, 0.03 m), SF4 (32.4 g) and HF (5.6 ml). The mixture was heated at 120 for eight hours. After cooling to 25, the bomb was vented and the contents poured onto ice. The solution was neutralized with saturated Na2 CO3 solution and extracted with CH2 Cl2. The organic layer was dried over Na2 SO4, filtered and the solvent distilled off on a steam bath. The residue was distilled at 115 (760 mm) to yield 1.4 g (23% yield) of 2-chloro-3-fluoro-5-trifluoromethylpyridine.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 38186-86-6, 6-Chloro-5-fluoronicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Merck & Co., Inc.; US4279913; (1981); A;,
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