Synthetic Route of 866319-00-8 ,Some common heterocyclic compound, 866319-00-8, molecular formula is C7H5FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
i) 5-Fluoro-1H-pyrrolo[2,3-b]pyridine 7-oxide may be prepared in the following manner: 6.22 g of 3-chloroperbenzoic acid are added to a solution of 2.7 g of 5-fluoro-1H-pyrrolo[2,3-b]pyridine in 70 cm3 of dimethoxyethane. The reaction medium is stirred in the region of 20 C. for 1 hour 30 minutes. After addition of a solution of 2 g of potassium hydroxide in 20 cm3 of methanol, the mixture is extracted with 5 times 100 cm3 of ethyl acetate. The organic phases are then washed with twice 15 cm3 of saturated ammonium chloride solution and then dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (13 kPa) The residue is purified by flash chromatography on a column of silica [eluent: dichloromethane/methanol (95/5 by volume)], and 3.6 g of a solid are obtained, which is washed with 25 cm3 of diethyl oxide and then dewatered and dried. The residue is purified by flash chromatography on a column of silica [eluent: cyclohexane/ethyl acetate (50/50 by volume)], and 1.70 g of 5-fluoro-1H-pyrrolo[2,3-b]pyridine 7-oxide are obtained in the form of a powder, the characteristics of which are as follows: Melting point: melting at 178 C. (Koefler block) IR spectrum: KBr 3128; 3085; 2919; 2863; 2734; 2629; 2406; 1588; 1507; 1349; 1256; 1206; 1129; 1077; 990; 804; 723; 670 and 466 cm-1
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 866319-00-8, 5-Fluoro-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Aventis Pharma S.A.; US2007/93480; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem