Development of an ionization method using hydrogenated plasma for mass analysis of surface adhesive compounds was written by Aida, Mari;Iwai, Takahiro;Okamoto, Yuki;Miyahara, Hidekazu;Seto, Yasuo;Okino, Akitoshi. And the article was included in Journal of Analytical Atomic Spectrometry in 2018.Synthetic Route of C8H11N This article mentions the following:
Currently, atm. plasmas are applied to the desorption and ionization of surface adhesive materials for rapid and highly sensitive anal. One widely used chem. ionization method applies protons generated from atm. water mols. to a desorbed sample; however, a detailed study of the ionization mechanism has not been addressed thus far. Therefore, this paper proposes an ionization method that adds a small, optimized amount of hydrogen to the helium plasma for generating protons in the sample ionization source. Using this technique, mass spectrometry was performed on the sample surface deposits of 2-isopropylpyridine and 4-isopropylaniline. The hydrogen flow rate was optimized to the addition ratio of 2%, and the lowest limit of detection achieved is 0.1 and 42 pmol for 2-isopropylpyridine and 4-isopropylaniline, resp. By optimizing the hydrogen addition flow rate, the optimum number of protons for sample ionization was attained, and it became possible to realize control of proton content in the sample, irresp. of humidity and surrounding environmental factors during mass spectrometry. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Synthetic Route of C8H11N).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C8H11N