Related Products of 13603-44-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13603-44-6, name is 2,6-Dimethylpyridin-4-ol. A new synthetic method of this compound is introduced below.
2,6-Dimethyl-pyridin-4-yl trifluoromethanesulfoiiate (91)A suspension of pyridone 90 (5.0 g, 40.6 mmol) in DCM (100 mL) at O0C was treated with triethylamine (8.50 mL, 60.9 mmol) followed by trifluoromethane- sulfonic anhydride (10.2 mL, 60.9 mmol), added dropwise via syringe over 5 minutes. After warming to RT and stirring 2 h, the reaction mixture was washed with aqueous NaHCO3 (3 x 100 mL) and reduced in vacuo to afford the title compound.Yield: 9.25 g (quant.).LC/MS ttau 0.96 min.MS(ES+) m/z 256 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13603-44-6, 2,6-Dimethylpyridin-4-ol, and friends who are interested can also refer to it.
Reference:
Patent; WYETH; WO2007/89669; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem