Analyzing the synthesis route of Methyl 2,6-dimethylisonicotinate

At the same time, in my other blogs, there are other synthetic methods of this type of compound,142896-15-9, Methyl 2,6-dimethylisonicotinate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 142896-15-9, Methyl 2,6-dimethylisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H11NO2, blongs to pyridine-derivatives compound. Computed Properties of C9H11NO2

General procedure: Compound 100: 3-(2,6-Dimethyl-pyridin-4-yl)-3-oxo-propionitrile. Compound 100 was obtained according to general procedure VII(ii) starting from compound 99. Compound 100 was used in the next step without further purification. M/Z (M+H)+ = 175.2. Method (ii): Under anhydrous condition, to a solution of acetonitrile (2.0 equiv.) in THF (c=0.4 mol.L-1) cooled at -78C, BuLi (1.6N in hexane – 2 equiv.) was added dropwise. The reaction mixture turned light beige. The mixture was stirred for 1 hour at -78C, then the acid derivative (acid chloride or ester – 1.0 equiv.) was added dropwise. The reaction mixture was stirred at -78C for 1 hour, after which time it was allowed to warm to 0C and hydrolysed with AcOH. The reaction mixture was concentrated, dried under reduced pressure at 50C with P2O5 for 18 hours.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,142896-15-9, Methyl 2,6-dimethylisonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Domain Therapeutics; Mayer, Stanislas; Schann, Stephan; EP2666775; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem