Electric Literature of 3719-45-7 , The common heterocyclic compound, 3719-45-7, name is 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid, molecular formula is C7H7NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of l-methyl-6-oxo-l,6-dihydropyridine-3-carboxylic acid (470 mg, 3.07 mmol) in 20 mL of dioxane was added Boc anhydride (1.34 g, 6.14 mmol), ammonium bicarbonate (485 mg, 6.14 mmol), and pyridine (0.496 mL, 6.14 mmol). The reaction mixture was stirred at ambient temperature for 18 h and then the resultant slurry was filtered to afford the title compound as a grey solid that was used in subsequent steps as is. MS: mlz = 153.1 [M+l]+.
The synthetic route of 3719-45-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CROWLEY, Brendan; FRALEY, Mark; POTTEIGER, Craig; LIM, John; SHERER, Ed; YU, Younong; MITCHELL, Helen; BIFTU, Tesfaye; NAIR, Anilkumar; WANG, Cheng; YANG, De-Yi; ZHU, Cheng; KAR, Nam Fung; HUANG, Xianhai; CHEN, Lei; ZHOU, Wei; PARK, Min, K.; CAI, Jiaqiang; WO2015/161014; (2015); A1;,
Pyridine – Wikipedia,
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