Electric Literature of 1042141-37-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1042141-37-6, name is Methyl 2-bromoimidazo[1,2-a]pyridine-6-carboxylate, molecular formula is C9H7BrN2O2, molecular weight is 255.07, as common compound, the synthetic route is as follows.
A mixture of methyl S-bromo-lJ-diazabicyclo^.S.Ojnona^^ojS-tetraene-S-carboxylate (0.65 mmol, 165 mg), tert-but5d N-methyl-N-[5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)pyridin-2-yl]carbamate (0.98 mmol, 312 mg), Pd(dprhof)Cl2*DCM (65 mumol, 53mg) and cesium carbonate (1.95 mmol, 656 mg) in DMF (5 mL) was heated at 80 CC under an argon atmosphere for 1 h. The reaction mixture was filtered and the solvent was evaporated in vacuo. The residue was purified by silica gel chromatography (EtOAc / hep) to give 150 mg of methyl 2-[6-[methyl-[(2-methylpropan- 2-yl)oxycarbonyl]amino]pyridin-3-yl]imidazo[2,l-fJpyridine-6-carboxylate as a yellow solid. MS m/z (M+H) 383
The chemical industry reduces the impact on the environment during synthesis 1042141-37-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; WO2008/91195; (2008); A1;,
Pyridine – Wikipedia,
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