Application of 188577-69-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 188577-69-7, name is 3,4-Dichloropyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.
2,7,8-Trichloro-imidazo[1,2-a]pyridine (17). 2-Amino-3,4-dichloropyridine, compound 5 (1.0 g, 6.1 mmol) was treated with ethyl bromoacetate (5.0 mL, 45.0 mmol) at 60 C. for 24 hours to give a white solid. This solid was removed by filtration, dissolved in water, treated with ion exchange resin and chlorinated with POCl3 as described above to give, after purification by flash chromatography (EtOAc/hexane 1:2, 15 cm*4 cm) and recrystallization from MeOH, 700 mg (52%) of compound 17 as white crystals. Compound 17: mp 220-221 C.; Rf 0.29 (EtOAc/hexane 1:2); 1H-NMR (360 MHz, CDCl3) delta7.93 (d, 1H J=7.15 Hz), 7.56 (s, 1H), 6.94 (d, 1H, J=7.15 Hz); 13C-NMR (90 MHz CDCl3) delta141.77 (C8a), 137.20 (C2), 129.87 (C7), 123.52 (C5), 121.30 (C8), 115.08 (C6), 110.39 (C3); UV lambdaax (EtOH) 304 (5250), 288 (5825), 233 (10434); (pH 11) 287 (6566), 232 (24612); (pH 1) 287 (8865), 231 (26610); HRMS m/z calcd for C7H3Cl3N2 219.9362, found 219.9355. Anal. Calcd for C7H3Cl3N2.1/4 H2O: C, 37.21; H, 1.56; N, 12.40. Found: C, 37.40; H, 1.46; N, 12.22.
According to the analysis of related databases, 188577-69-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; The Regents of the University of Michigan; US6214801; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem