Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-[4-(substituted amino)phenylalkyl] ester derivatives was written by Ashimori, Atsuyuki;Ono, Taizo;Inoue, Yoshihisa;Morimoto, Satoshi;Eda, Masahiro;Uchida, Takeshi;Ohtaki, Yutaka;Fujino, Yoshiyuki;Kido, Hideaki. And the article was included in Chemical & Pharmaceutical Bulletin in 1991.Related Products of 116308-35-1 This article mentions the following:
Novel 1,4-dihydropyridine derivatives bearing 3-[4-(substituted amino)phenylalkyl] ester side chains were prepared by several routes and tested for antihypertensive activity in spontaneously hypertensive rats. Most compounds showed a more potent antihypertensive effect and a longer duration of action than nicardipine. The derivatives with a benzhydrylpiperazinyl and a benzhydrylpiperidinyl group were distinctive. [(Benzhydrylpiperazinyl)phenyl]alkyl and [(benzhydrylpiperidinyl)phenyl]alkyl dihydrodimethylpyridinedicarboxylates I (R = 3-O2NC6H4, X = N, X1 = NCHPh2, n = 2; R = 4-cyano-2-pyridyl, X = N, X1 = NCHPh2, n = 2; R = 3-O2NC6H4, X = N, X1 = NCHPh2, n = 3; R = 3-O2NC6H4, X = N, X1 = CHCHPh2, X = CH, X1 = NCHPh2, n = 2) were selected as candidates for further pharmacol. investigations. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1Related Products of 116308-35-1).
2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 116308-35-1