The author of 《Selective C-C bond formation from rhodium-catalyzed C-H activation reaction of 2-arylpyridines with 3-aryl-2H-azirines》 were Baek, Yonghyeon; Kim, Jinwoo; Hyunseok Kim; Jung, Seung Jin; Ryu, Ho; Kim, Suyeon; Son, Jeong-Yu; Um, Kyusik; Han, Sang Hoon; Seo, Hyung Jin; Heo, Juyoung; Lee, Kooyeon; Baik, Mu-Hyun; Lee, Phil Ho. And the article was published in Chemical Science in 2019. Formula: C6H6BrN The author mentioned the following in the article:
A novel method for the synthesis of acylmethyl-substituted 2-arylpyridine derivatives I [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = 4-Me, 5-C(O)Me, 5-CF3, etc.; R3 = H, Me, F, C(O)Me, CO2Et] was synthesized via rhodium-catalyzed C-H activation reaction of 3-aryl-2H-azirines with 2-arylpyridines and explored a prototype reaction using DFT-calculations Computational studies quickly revealed and prototype exptl. work confirmed that neither the formation of the expected metal nitrene complexes nor the C-N coupling were viable. Instead, azirine ring-opening followed by C-C coupling was found to be much more favorable to give imines that readily underwent hydrolysis in aqueous conditions to form compounds I. This new method was highly versatile and selective toward a wide range of substrates with high functional group tolerance. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Formula: C6H6BrN