Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS was written by Bencheva, Leda Ivanova;De Matteo, Marilenia;Ferrante, Luca;Ferrara, Marco;Prandi, Adolfo;Randazzo, Pietro;Ronzoni, Silvano;Sinisi, Roberta;Seneci, Pierfausto;Summa, Vincenzo;Gallo, Mariana;Veneziano, Maria;Cellucci, Antonella;Mazzocchi, Nausicaa;Menegon, Andrea;Di Fabio, Romano. And the article was included in ACS Medicinal Chemistry Letters in 2019.COA of Formula: C6H3FN2 This article mentions the following:
Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chem. starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound I is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6COA of Formula: C6H3FN2).
6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C6H3FN2