Bobbio, Carla published the artcileSelective Functionalization of 2-Fluoropyridine, 2,3-Difluoropyridine, and 2,5-Difluoropyridine at Each Vacant Position, Computed Properties of 851386-45-3, the publication is Journal of Organic Chemistry (2005), 70(8), 3039-3045, database is CAplus and MEDLINE.
The concept of “regioexhaustive substitution” has been successfully applied to 2-fluoro-, 2,3-difluoro-, and 2,5-difluoropyridine. All vacant positions were amenable to regioselective metalation and subsequent carboxylation by employing either chlorine as a neighboring site activating protective group or trimethylsilyl as a neighboring site screening protective group. In this way, approx. half a dozen fluorinated pyridinecarboxylic acids were derived from each starting material.
Journal of Organic Chemistry published new progress about 851386-45-3. 851386-45-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Carboxylic acid, name is 3,6-Difluoropicolinic acid, and the molecular formula is C6H3F2NO2, Computed Properties of 851386-45-3.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem