Bordallo, Eduardo published the artcileDissolution of amorphous nifedipine from micelle-forming carboxymethylcellulose derivatives, Quality Control of 21829-25-4, the main research area is self assembly amphiphilic polyethylene glycol graft oxidized CM cellulose; micelle CMC graft polyoxyethylene dodecylamine terminated nifedipine; Amphiphilic graft copolymers; Encapsulation; Lipophilic drug; Micelles; Nifedipine; Photostabilization.
We show that a novel amphiphilic graft copolymer combining the biodegradability and biocompatibility of oxidized CM-cellulose (CMC) with that of hydrophilic poly(ethylene glycol) (PEG), and hydrophobic dodecylamine (DDA), improves the solubility and dissolution performance of nifedipine (NIF), considered as a model hydrophobic drug. The hydrophobic components of the graft copolymer have the multiple effect of favoring micelle formation and loading. At the same time, the interaction between the hydrophobic core and NIF has the secondary effect to suppress drug crystallization, favoring its dissolution, and to increase photostability. Oxidized CMC-g-PEG-DDA micelles reached values of drug concentration, loading capacity and encapsulation efficiency as high as 340μg mL-1, 6.4% and 34.1%, resp. Loaded micelles showed a good stability with a limited release profile at pH 1.2, whereas at pH 7.4 the swollen cores enable much higher and progressive release, that reaches 3.4 and 6.6% after 3 and 5 h, resp., corresponding to very competitive concentration of 34 and 66μg mL-1. A series of oxidized CM-cellulose-graft-poly(ethylene glycol)-dodecylamine (OCMC-g-PEG-DDA) was prepared by using an appositely prepared PEG with terminal amino groups and different amounts of DDA. The nanoaggregates formed in aqueous solution were characterized by surface tension measurements, fluorescence spectroscopy, dynamic light scattering (DLS) and scanning electron microscopies (SEM and TEM). The micelles showed narrow hydrodynamic size distributions and diameters varying from 163 to 193 nm depending on the ratio of DDA to PEG chains. The DDA content in the graft copolymers also affected the core-shell interfacial compactness.
Carbohydrate Polymers published new progress about Biocompatibility. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Quality Control of 21829-25-4.