As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54903-50-3, name is 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine, molecular formula is C7H9NS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine
To a stuffing solution of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine (5.6 g, 40.3 mmol), and Et3N (6.1 g, 60.4 mmol) in MeOH (100 mL) was added Boc2O (10.5g, 48.4 mmol) in 30 mm at 0 C. The mixture was stuffed at 20 C for 16 hours. The reaction mixture was concentrated after the starting material was consumed and the residue re-dissolved in DCM, the organic solution washed with water and aq. HC1 (0.5 M), the organic phases was dried and concentrated to give 8.9 g (yield: 92.4%) of tert-butyl 6,7-dihydrothieno[3,2-c]pyridine- 5(4H)-carboxylate as white solid. ?H NMR (400MHz, CDC13) (ppm): 7.14 (d, 1=5.0 Hz, 1H), 6.81 (d, 1=5.0 Hz, 1H), 4.52 (br. s, 2H), 3.75 (br. s, 2H), 2.87 (br. s, 2H), 1.51 (s, 9H). LCMS (mlz): 240.2 [M+H]
With the rapid development of chemical substances, we look forward to future research findings about 54903-50-3.
Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; SHAPIRO, Gideon; (393 pag.)WO2015/200677; (2015); A2;,
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