Reference of 286946-77-8 ,Some common heterocyclic compound, 286946-77-8, molecular formula is C5H3BrClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 65 5-bromo-2-chloropyridin-3-ol (50.2 g, 241 mmol) in 56 N,N-dimethylformamide (200 mL) were added successively 66 benzyl bromide (33.0 mL, 278 mmol) and 67 potassium carbonate (48.6 g, 352 mmol), and the mixture was stirred at room temperature for 4 hr. To the reaction solution was added 14 water (600 mL), and the mixture was stirred for 2 hr. The precipitate was collected by filtration, and dried under reduced pressure to give 68 3-(benzyloxy)-5-bromo-2-chloropyridine (69.7 g, yield 96%). 1H-NMR (DMSO-D6) delta: 5.29 (2H, s), 7.33-7.47 (5H, m), 7.98 (1H, d, J=2.1 Hz), 8.14 (1H, d, J=1.8 Hz)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 286946-77-8, 5-Bromo-2-chloropyridin-3-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JAPAN TOBACCO INC.; NAGAMORI, Hironobu; NISHIMARU, Tatsuya; TAKAGI, Masaki; MITANI, Ikuo; NAKAGAWA, Yuichi; US2019/152926; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem