Reference of 623942-84-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623942-84-7, name is (3-Bromo-6-methoxypyridin-2-yl)methanol, molecular formula is C7H8BrNO2, molecular weight is 218.05, as common compound, the synthetic route is as follows.
(3-bromo-6-methoxypyridin-2-yl)methanol (2.5 g, 11.4 mmol) and CBr4 (4.5 g, 13.6 mmol) were added into DCM (30 mL). PPh3 (3.6 g, 13.6 mmol) in DCM (10 mL) was added dropwise into the reaction mixture at 0 C. The mixture was stirred at 0 C for 0.5 hour. The reaction was concentrated to give a residue. The residue was purified by flash silica gel chromatography (40 g column, EtOAc in petroleum ether from 0% to 10%) to afford 3- bromo-2-(bromomethyl)-6-methoxypyridine (2.69 g, 84% yield) as a colorless oil. LCMS m/z [M+H]+ = 281.8.
Statistics shows that 623942-84-7 is playing an increasingly important role. we look forward to future research findings about (3-Bromo-6-methoxypyridin-2-yl)methanol.
Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; TAYLOR, Alexander, M.; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; WALTERS, W., Patrick; MURCKO, Mark, Andrew; MCLEAN, Thomas, H.; GUNAYDIN, Hakan; GIORDANETTO, Fabrizio; THERRIEN, Eric; (607 pag.)WO2019/183367; (2019); A1;,
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