Application of 65001-21-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65001-21-0, name is 5-Bromopyridine-3-sulfonyl chloride, molecular formula is C5H3BrClNO2S, molecular weight is 256.51, as common compound, the synthetic route is as follows.
Step 3 – Preparation of 3-[l-(5-bromo pyridine-3-sulfonyl)-5-chloro-lH-indol-3-yl] propionic acid methyl ester (11); [0176] Into a flask, 3-(5-chloro-lH-indol-3-yl)-propionic acid methyl ester (11, 150 mg, 0.00063 mol), and tetrabutyl ammonium hydrogen sulfate were dissolved in 20 mL of dichloromethane and 20 mL of 50% KOH solution was added. The solution was mixed vigorously and 5-bromo- pyridyl-3-sulfonyl chloride (10, 240 mg, 0.00095 mol) was slowly added to the reaction. After 5-6 minutes of vigorous stirring, precipitates began to form. An additional 3-4 mL of 50% KOH was added and the reaction was stirred overnight. TLC (30% ethyl acetate/hexane) showed that the starting material had disappeared. The reaction mixture was extracted with 3 x 50 mL of dichloromethane and the organic layers were combined and washed with water, brine, and dried over MgSO4. The organic layer was filtered and roto evaporated to half its volume. Silica was added and the solvent completely removed. Chromatography was run using a gradient solvent condition of 0 to 20% ethyl acetate/hexane over 15 minutes, then 20 to 45% over 15 minutes. The desired compound was isolated. 1H NMR consistent with structure.
Statistics shows that 65001-21-0 is playing an increasingly important role. we look forward to future research findings about 5-Bromopyridine-3-sulfonyl chloride.
Reference:
Patent; PLEXXIKON, INC.; WO2008/109700; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem