Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89026-78-8, name is 6-Chloro-N-methylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 6-Chloro-N-methylpyridin-2-amine
6-Chloro-N-methylpyridin-2-mine (11.5 g, 0.081 mol) and phenylboronic acid (16 g, 0.131 mol) were mixed in 160 mL DME, after degassed by N2 for 10 min, 1,1-bis(diphenylphosphino)ferrocenedichloropalladium(II) (5 g, 6.12 mmol) was mixed, the heterogeneous solution was heated to reflux for 3 h. The mixture was concentrated under vacuum and the resulting oil was poured into saturated ammonium chloride and extracted (EtOAc, 2*). The combined organic layers were washed with saturated sodium bicarbonate, followed by brine. The resulting organic layers collected, dried over Na2SO4 and concentrated in vacuum. The crude product was purified with flash column chromatography (4:1 hexane/EtOAc) to give the title compound as an off-white solid. MS m/z 185 (MH)+.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89026-78-8, 6-Chloro-N-methylpyridin-2-amine.
Reference:
Patent; Andersen, Denise Lyn; Chang, Catherine H.; Falsey, James R.; Frohn, Michael J.; Hong, Fang-Tsao; Liao, Hongyu; Liu, Longbin; Lopez, Patricia; Retz, Daniel Martin; Rishton, Gilbert M.; Rzasa, Robert M.; Siegmund, Aaron; Tadesse, Seifu; Tamayo, Nuria; Tegley, Christopher M.; US2006/69110; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem