Category: 1000341-55-8

Electric Literature of 1000341-55-8 ,Some common heterocyclic compound, 1000341-55-8, molecular formula is C7H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) Preparation of intermediate 10A stirred solution of 6-chloro-3-iodo-5-azaindole (1.00 g, 3.56 mmol) in DMF (35 ml) at 0 C, was treated with sodium hydride (60%> in mineral oil, 0.17 g, 4.31 mmol). After stirring at 0 C for 10 minutes, the mixture was treated with p-toluenesulfonyl chloride (0.75 g, 3.95 mmol), then warmed to ambient temperature over 30 minutes. The reaction was quenched by the addition of water, then partitioned between EtOAc and dilute aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0: 1 to 6:4 by volume), to afford the desired product as a white solid (1.18 g, 76%).LCMS (Method B): Rt= 4.19 min, m/z [M+H]+= 433/435

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1000341-55-8, 6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; TISSELLI, Patrizia; CLARK, David, Edward; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; PANCHAL, Terry, Aaron; PRICE, Stephen, Colin; MONTANA, John, Gary; WO2015/44267; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1000341-55-8 ,Some common heterocyclic compound, 1000341-55-8, molecular formula is C7H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) Preparation of intermediate 10A stirred solution of 6-chloro-3-iodo-5-azaindole (1.00 g, 3.56 mmol) in DMF (35 ml) at 0 C, was treated with sodium hydride (60%> in mineral oil, 0.17 g, 4.31 mmol). After stirring at 0 C for 10 minutes, the mixture was treated with p-toluenesulfonyl chloride (0.75 g, 3.95 mmol), then warmed to ambient temperature over 30 minutes. The reaction was quenched by the addition of water, then partitioned between EtOAc and dilute aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0: 1 to 6:4 by volume), to afford the desired product as a white solid (1.18 g, 76%).LCMS (Method B): Rt= 4.19 min, m/z [M+H]+= 433/435

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1000341-55-8, 6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; TISSELLI, Patrizia; CLARK, David, Edward; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; PANCHAL, Terry, Aaron; PRICE, Stephen, Colin; MONTANA, John, Gary; WO2015/44267; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1000341-55-8, 6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1000341-55-8, blongs to pyridine-derivatives compound. SDS of cas: 1000341-55-8

Into a 100 mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was added a solution of 6-chloro-3-iodo-lH-pyrrolo[3,2-c]pyridine (1.70 g, 6.10 mmol) in N,N-dimethylformamide (20.0 mL) followed by sodium hydride (600 mg, 25.0 mmol). This was followed by addition of 2-iodopropane (2.20 g, 12.9 mmol) dropwise with stirring at 0 C. The reaction mixture was stirred for 16 h at room temperature. The reaction was then quenched by addition of water (50mL). The resulting solution was extracted with ethyl acetate (3×50 mL) and the organic layers were separated and combined. The combined organic layer was washed with brine (100 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by silica gel chromatography with ethyl acetate/petroleum ether (1 :7) to afford the title compound (1.40 g, 72.0 %) as a yellow solid. LCMS (ESI): RT (min) = 1.549, [M+H]+ = 321, method = M.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1000341-55-8, 6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M.; WO2014/81718; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem