Category: 1003-56-1

A new synthetic route of 3-Methylpyridin-2(1H)-one

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1003-56-1, its application will become more common.

Related Products of 1003-56-1 ,Some common heterocyclic compound, 1003-56-1, molecular formula is C6H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 5: 1-(4-chlorobutyl)-3-methyl-2(1H)-pyridinone (Prep5); To a solution of 3-methyl-2(1 H)-pyhdinone (commercial aldrich) (200 mg, 1.85 mmol), in dry DMF (5 mL), K2CO3 (0.51 g) and 1-bromo-3-chlorobutane (0.32 mL) were added and the resulting mixture was heated at 90 C for 5 hours After solvent elimination under reduced pressure, the residue was diluted with ethyl acetate and washed once with water and once with brine The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure The crude product was purified by silica gel chromatography eluting with cyclohexane/EtOAc 8 2 to give the title compound as colourless oil (0 24 g) MS (m/z): 200 [MH]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1003-56-1, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/113258; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem