Category: 10128-71-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10128-71-9, name is 3-Hydroxyisonicotinic acid, the common compound, a new synthetic route is introduced below. Computed Properties of C6H5NO3

A solution of 3-hydroxyisonicotinic acid (495 g, 3.56 mol) in EtOH (7 L) and concentrated H2SO4 (250 mL) was heated under reflux for 72 h and then cooled to rt and concentrated under reduced pressure to remove the solvent. The residue was dissolved in water (3 L) and the pH was adjusted to 4 by addition of saturated aqueous NaHCO3 solution. The resulting precipitate was removed by filtration and the filtrate was extracted with DCM (2 Lx3 ). The combined organic phase was washed with brine, dried over anhydrous Na2SO4 and then concentrated under reduced pressure to give ethyl 3-hydroxyisonicotinate (414 g, 70%) as yellow oil.

The synthetic route of 10128-71-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; DRAGOVICH, Peter; GOSSELIN, Francis; GUNZNER-TOSTE, Janet; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZAK, Mark; ZHANG, Yamin; ZHAO, Guiling; ZHENG, Xiaozhang; YUEN, Po-Wai; WO2013/127266; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 10128-71-9 ,Some common heterocyclic compound, 10128-71-9, molecular formula is C6H5NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: According to a typical procedure, in a 100 mL round bottom flask, 2 g (13.06 mmol) of the acid 16 were added to 30 mL of acetone. The mixture was alkalized with a 20% NaOH solution to completely dissolve the acid. 0.82 mL (13.1 mmol, 1.87 g) of commercial CH3I were then added and the reaction mixture was stirred at room temperature for about 4 h. The solvent was moved off in a rotary evaporator and the residue was taken up in a small volume of distilled water (30 mL), acidified with 2 M HCl and stirred with slight heating for about 30 min. After concentration of the solution to about a half volume in a rotary evaporator, the formed solid product was collected by filtration, and a white residue was obtained. To remove the NaCl present as an impurity, the residue was treated with a small volume of absolute ethanol (15 mL), the suspension was filtered, and to the filtrate was added an excess of diethyl ether, obtaining the precipitation of the desired compound. This was collected and dried under vacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10128-71-9, 3-Hydroxyisonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Brun, Paola; Dean, Annalisa; Di Marco, Valerio; Surajit, Pathak; Castagliuolo, Ignazio; Carta, Davide; Ferlin, Maria Grazia; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 486 – 497;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 10128-71-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10128-71-9, name is 3-Hydroxyisonicotinic acid, molecular formula is C6H5NO3, molecular weight is 139.11, as common compound, the synthetic route is as follows.

Acetyl chloride (20 mE) was added dropwise to methanol (200 mE) at 00 C. After the addition, the reaction mixture was stirred at this temp for 15 mm and then 4.0 g of the acid was added. The reaction mixture was heated at reflux for 12 h. Methanol was removed to give a residue, which was then carefully neutralized with aq. sat. NaRCO3 and then extracted with EtOAc (3x). The organic layers were combined, dried and evaporated to give the ester as a yellow solid, which was used in the next step without further purification.

Statistics shows that 10128-71-9 is playing an increasingly important role. we look forward to future research findings about 3-Hydroxyisonicotinic acid.

Reference:
Patent; Global Blood Therapeutics, Inc.; The Regents of the University of Califorina; Cytokinetics, Inc.; Metcalf, Brian; Chuang, Chihyuan; Warrington, Jeffrey; Paulvannan, Kumar; Jacobson, Matthew P.; Hua, Lan; Morgan, Bradley; US2015/344483; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem