Synthetic Route of 1020253-15-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1020253-15-9, name is 4-Bromo-2-chloro-5-methoxypyridine, molecular formula is C6H5BrClNO, molecular weight is 222.47, as common compound, the synthetic route is as follows.
Step 105.2: 4-Bromo-5-methoxy-1-methyl-1 H-pyridin-2-one A solution of 4-bromo-2-chloro-5-methoxypyridine (1 g, 4.5 mmol) in dimethyl sulfate (1.9 mL, 19.5 mmol) was stirred at 120C for 16 h in a sealed tube. After cooling, acetonitrile and a saturated aqueous NaHC03 solution were added and the mixture was stirred at rt over week-end. DCM was added and extracted. The organic layer was dried (Na2S04), filtered and concentrated to give the title compound. tR: 0.57 min (LC-MS 2); ESI-MS: 218.0/220.0 [M+H]+ (LC-MS 2).
The chemical industry reduces the impact on the environment during synthesis 1020253-15-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; KALLEN, Joerg; LIAO, Lv; MAH, Robert; MAO, Liang; MASUYA, Keiichi; SCHLAPBACH, Achim; STUTZ, Stefan; VAUPEL, Andrea; WO2013/111105; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem