Category: 103-74-2

COA of Formula: C7H9NOIn 2022 ,《Synthesis of Substituted Pyrano[3,4-b]Quinolines by Silver-Catalyzed Regioselective Intramolecular Cyclization of 3-Alkynylquinoline Aldehydes》 appeared in Asian Journal of Organic Chemistry. The author of the article were Vani, Damera; Chahal, Kapil; Preethi, Pagilla; Balasubramanian, Sridhar; Rajender Reddy, Kallu. The article conveys some information:

A novel approach for the synthesis of regioselective pyrano[3,4-b]quinolines from 3-alkynylquinoline aldehydes with alcs. as nucleophiles were elucidated. This protocol showed high generality of functional group and provided the pyrano-annulated products good to excellent yields. This methodol. was adopted a new synthetic strategy to develop the 3-alkynylquinolinealdehydes by using methanol as a C1 source. The results came from multiple reactions, including the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-(2-Hydroxyethyl)pyridineIn 2019 ,《Highly Chemoselective gem-Difluoropropargylation of Aliphatic Alcohols》 appeared in Chemistry – A European Journal. The author of the article were Okamura, Toshitaka; Egoshi, Syusuke; Dodo, Kosuke; Sodeoka, Mikiko; Iwabuchi, Yoshiharu; Kanoh, Naoki. The article conveys some information:

α,α-Difluoropropargyl ethers were prepared by complexation of 3-bromo-3,3-difluoro-1-alkynes with dicobalt octacarbonyl, etherification with alcs. and decomplexation. Despite the potential of α-fluoroethers in medicinal chem., their synthetic methods, especially etherification of aliphatic alcs., have been limited. Herein, we developed two- and three-step gem-difluoropropargylation of aliphatic alcs. including amino acid derivatives and naturally occurring bioactive mols. Highly chemoselective etherification proceeded by using the gem-difluoropropargyl bromide dicobalt complex in the presence of silver triflate and triethylamine. Decomplexation of dicobalt complexes was achieved by using cerium ammonium nitrate or N,N,N’-trimethylethylenediamine. The thus obtained gem-difluoropropargyl ethers were converted to various α-difluoroethers which are expected to be useful for medicinal chem. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 103-74-2In 2018 ,《Solid-Phase Synthesis of Tetramic Acid via Resin-Bound Enol Ethers as a Privileged Scaffold in Drug Discovery》 was published in Advanced Synthesis & Catalysis. The article was written by Schuetznerova, Eva; Oliver, Allen G.; Pribylka, Adam; Krchnak, Viktor. The article contains the following contents:

This paper reports the practical synthesis of a tetramic acid scaffold on solid phase using simple, com. available building blocks under mild conditions. Acyclic precursors were assembled on solid phase in four steps, and cyclization was achieved by Wittig olefination. The target compounds contained three points of diversification and allowed for further modifications while still being attached to the resin. Solid-phase synthesis represents a method of choice, particularly for parallel synthesis, because the intermediates can be isolated simply and quickly by washing the resin beads, which typically takes only minutes.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Malik, Magdalena; Bienko, Dariusz C.; Komarnicka, Urszula K.; Kyziol, Agnieszka; Drys, Magdalena; Switlicka, Anna; Dyguda-Kazimierowicz, Edyta; Jedwabny, Wiktoria published an article in 2021. The article was titled 《Synthesis, structural characterization, docking simulation and in vitro antiproliferative activity of the new gold(III) complex with 2-pyridineethanol》, and you may find the article in Journal of Inorganic Biochemistry.Name: 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

Gold(III) complex containing 2-pyridineethanol has been synthesized and characterized structurally by single crystal X-ray diffraction, vibrational spectroscopy, 1H NMR spectroscopy, electrochem. study, and DFT calculations The Au(III) ion is four coordinated with one N-donor ligand (L) and three Cl anions. The Okuniewski′s has been used to estimate the angular distortion from ideal square planar geometry. The vibrational spectroscopy studies, in the solid state and DMSO solution and cyclic voltammetry, have been performed to determine its stability and redox activity, resp. A complete assignment of the IR and Raman spectra has been made based on the calculated potential energy distribution (PED). The theor. calculations have been made for two functionals and several basis sets. The compound has been evaluated for its antiproliferative properties in a human lung adenocarcinoma cell line (A549), mouse colon carcinoma (CT26), human breast adenocarcinoma (MCF-7), human prostate carcinoma derived from the metastatic site in the brain (DU-145), and PANC-1 human pancreas/duct carcinoma cell line and non-tumorigenic cell lines: HaCat (human keratinocyte), and HEK293T (human embryonic kidney). Au(III) complex cytotoxicity is significantly against A549 and MCF-7 cells as in the reference drug: cisplatin. Studies of the interactions of Au(III) complex with DNA, HSA (human serum albumin) have been performed. The results from modeling docking simulations indicate that the title complex exerts anticancer effects in vitro based on different mechanisms of action to compare with cisplatin. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C7H9NOIn 2019 ,《Merging Photochemistry with Electrochemistry: Functional-Group Tolerant Electrochemical Amination of C(sp3)-H Bonds》 appeared in Angewandte Chemie, International Edition. The author of the article were Wang, Fei; Stahl, Shannon S.. The article conveys some information:

A combined electrochem./photochem. method for dehydrogenative C(sp3)-H/N-H coupling that exhibits good reactivity with both sp2 and sp3 N-H bonds has been reported. The results show how use of iodide as an electrochem. mediator, in combination with light-induced cleavage of intermediate N-I bonds, enables the electrochem. process to proceed at low electrode potentials. This approach significantly improves the functional-group compatibility of electrochem. C-H amination, for example, tolerating electron-rich aromatic groups that undergo deleterious side reactions in the presence of high electrode potentials. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Near-Infrared Fluorescent Theranostic Cisplatin Prodrug with Transcatheter Intra-Arterial Therapy: Application to Rabbit Hepatocellular Carcinoma》 was written by Li, Qiang; Wang, Qi; Wang, Saibo; Zhu, Shiqin; Yuan, Tianwen; Guo, Zhiqian; Cao, Jun; Tian, He; Zhu, Wei-Hong. HPLC of Formula: 103-74-2This research focused ontranscatheter intra arterial therapy cisplatin prodrug hepatocellular carcinoma. The article conveys some information:

Transcatheter intra-arterial therapy (TIT) has become valuable in the battle against primary and secondary hepatic malignancies. However, the lack of a mechanism to visualize real-time drug release and avoid fast metabolic clearance of chemotherapeutic agents is the primary barrier to TIT for hepatocellular carcinoma. Here, a specific near-IR (NIR) fluorescent prodrug platform, i.e., DSPE-mPEG/DCM-S-Pt micelles (DCM-S-Pt@PEG), to assist TIT in direct administration to large mammals like rabbits, is presented. DCM-S-Pt@PEG consists of a NIR fluorophore for tracing drug release, a nonspecific antitumor drug cisplatin for hepatocellular carcinoma treatment, a glutathione-activatable disulfide linker, and a DSPE-mPEG nano-micelle carrier for controllable drug release. DCM-S-Pt@PEGcan make the drug accumulation in tumor tissues enhance the therapeutic effect by: (i) specific delivery of prodrug to hepatic tumor tissues through the femoral artery by TIT, (ii) sustained drug-release from the biodegradable lipid DSPE-mPEG micelle to minimize metabolic clearance, and (iii) cancer biomarker-activated drug release. It provides a promising strategy to assist TIT in treating unresectable devastating hepatocellular carcinoma administration in the rabbit model, rather than common mouse model. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2HPLC of Formula: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.HPLC of Formula: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides》 was published in Organic Process Research & Development in 2020. These research results belong to Mathieu, Gary; Patel, Heena; Lebel, Helene. Related Products of 103-74-2 The article mentions the following:

The first continuous flow process was developed to synthesize N-Me secondary amines from alkyl mesylates and epoxides via a nucleophilic substitution using aqueous methylamine. A variety of N-Me secondary amines were produced in good to excellent yields, including a number of bioactive compounds, or their precursors. Up to 10.6 g (88% yield) of a N-Me secondary amine was produced in 140 min process time. The amination procedure included an in-line workup, and the starting mesylate material was also produced in continuous flow from the corresponding alc. Finally, an in-line process combining the mesylate synthesis and nucleophilic substitution was developed. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Naidu, B. Narasimhulu; Patel, Manoj; McAuliffe, Brian; Ding, Bo; Cianci, Christopher; Simmermacher, Jean; Jenkins, Susan; Parker, Dawn D.; Sivaprakasam, Prasanna; Khan, Javed A.; Kish, Kevin; Lewis, Hal; Hanumegowda, Umesh; Krystal, Mark; Meanwell, Nicholas A.; Kadow, John F. published an article in Journal of Medicinal Chemistry. The title of the article was 《Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs》.Category: pyridine-derivatives The author mentioned the following in the article:

The design, synthesis, and optimization of pyridine-based I [R = Ph, 4-MeC6H4, 4-ClC6H4, etc.] and II [R1 = 3-(4-fluorophenyl)propyl, 2-(4-fluorophenyl)ethylamino, 3-(4-fluorophenyl)propoxy, etc.] allosteric integrase inhibitors were reported. Optimization was conducted with a specific emphasis on the inhibition of the 124/125 polymorphs such that the designed compounds showed excellent potency in-vitro against majority of the 124/125 variants. In vivo profiling of promising preclin. lead I [R = 4-FC6H4] showed that it exhibited a good pharmacokinetic (PK) profile in preclin. species, which resulted in a low predicted human efficacious dose. However, findings in rat toxicol. studies precluded further development of I [R = 4-FC6H4]. The results came from multiple reactions, including the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C7H9NOIn 2019 ,《A biocatalytic synthesis of heteroaromatic N-oxides by whole cells of Escherichia coli expressing the multicomponent, soluble di-iron monooxygenase (SDIMO) PmlABCDEF》 was published in Advanced Synthesis & Catalysis. The article was written by Petkevicius, Vytautas; Vaitekunas, Justas; Tauraite, Daiva; Stankeviciute, Jonita; Sarlauskas, Jonas; Cenas, Narimantas; Meskys, Rolandas. The article contains the following contents:

Aromatic N-oxides (ArN-OX) are desirable biol. active compounds with a potential for application in pharmacy and agriculture industries. As biocatalysis is making a great impact in organic synthesis, there is still a lack of efficient and convenient enzyme-based techniques for the production of aromatic N-oxides. In this study, a recombinant soluble di-iron monooxygenase (SDIMO) PmlABCDEF overexpressed in Escherichia coli was showed to produce various aromatic N-oxides. Out of 98 tested N-heterocycles, seventy were converted to the corresponding N-oxides without any side oxidation products. This whole-cell biocatalyst showed a high activity towards pyridines, pyrazines, and pyrimidines. It was also capable of oxidizing bulky N-heterocycles with two or even three aromatic rings. Being entirely biocatalytic, our approach provides an environmentally friendly and mild method for the production of aromatic N-oxides avoiding the use of strong oxidants, organometallic catalysts, undesirable solvents, or other environment unfriendly reagents. The sequence of the p577A clone containing pmlABCDEF gene cluster was deposited in GenBank under the accession number MK037457. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Anion-Radical Salts of 7,7,8,8-Tetracyanoquinodimethane with Cations in the Basis of Alkylolpyridines》 was published in Russian Journal of General Chemistry. The article was written by Starodub, T. N.. The article contains the following contents:

Anion-radical salts of 7,7,8,8-tetracyanoquinodimethane with cations on the basis of methylol- and ethylolpyridines, N-methyl- and N-Et alkylolpyridines, were synthesized. Their composition is determined by the method of electronic spectroscopy, and the thermal stability is studied. The nature of the salts is investigated by the method of IR spectroscopy: it is shown that the conducting properties depend both on the nature of the alkyl group and on the position of the alkylol substituent. The presence of hydroxy groups in the conducting anion-radical salts allow their application as electronic organic materials for the design of conducting film coatings. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem