Category: 1042986-00-4

Electric Literature of 1042986-00-4, Adding some certain compound to certain chemical reactions, such as: 1042986-00-4, name is 2-Fluoro-5-methylnicotinic acid,molecular formula is C7H6FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1042986-00-4.

Step a To a cooled to 0 C. mixture of 4-amino-benzoic acid methyl ester (0.930 g, 61.7 mmol) and 2-fluoro-5-methylnicotinic acid (10.0 g, 64.5 mmol) was added a solution of HOBt (10.0 g, 74.0 mmol) in dry DMF (100 mL). EDC (11.0 g, 70.9 mmol) was added and the reaction mass was stirred overnight at room temperature. The resulting mixture was poured into cold water (600 mL). The precipitated solid was collected by filtration, washed with water, and dried in vacuum to obtain methyl 4-(2-fluoro-5-methylnicotinamido)benzoate (14.2 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1042986-00-4, 2-Fluoro-5-methylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Enanta Pharmaceuticals, Inc.; Kim, In Jong; yu, Jianming; Panarese, Joseph; McGrath, Kevin; Negretti-Emmanuelli, Solymar; Blaisdell, Thomas P.; Shook, Brian C.; Or, Yat Sun; US2019/2479; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1042986-00-4, Adding some certain compound to certain chemical reactions, such as: 1042986-00-4, name is 2-Fluoro-5-methylnicotinic acid,molecular formula is C7H6FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1042986-00-4.

Step a To a cooled to 0 C. mixture of 4-amino-benzoic acid methyl ester (0.930 g, 61.7 mmol) and 2-fluoro-5-methylnicotinic acid (10.0 g, 64.5 mmol) was added a solution of HOBt (10.0 g, 74.0 mmol) in dry DMF (100 mL). EDC (11.0 g, 70.9 mmol) was added and the reaction mass was stirred overnight at room temperature. The resulting mixture was poured into cold water (600 mL). The precipitated solid was collected by filtration, washed with water, and dried in vacuum to obtain methyl 4-(2-fluoro-5-methylnicotinamido)benzoate (14.2 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1042986-00-4, 2-Fluoro-5-methylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Enanta Pharmaceuticals, Inc.; Kim, In Jong; yu, Jianming; Panarese, Joseph; McGrath, Kevin; Negretti-Emmanuelli, Solymar; Blaisdell, Thomas P.; Shook, Brian C.; Or, Yat Sun; US2019/2479; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1042986-00-4, name is 2-Fluoro-5-methylnicotinic acid, molecular formula is C7H6FNO2, molecular weight is 155.13, as common compound, the synthetic route is as follows.Recommanded Product: 2-Fluoro-5-methylnicotinic acid

Intermediate 9:2-fluoro-N-methoxy-N,5-dimethylnicotinamide[00366] To a solution of 2-fluoro-5-methylnicotinic acid (4.9 g, 31.6 mmol), N,O- dimethylhydroxylamine hydrochloride (4.01 g, 41.08 mmol), diisopropylethylamine (12.6 ml, 72.68 mmol) in dichloromethane (150 ml) at 0C was added TBTU (11.16 g, 34.76 mmol) portionwise over 30 minutes. The solution was stirred at 0C for a further 10 minutes then, at room temperature for 18 hours. The reaction mixture was washed with a 10wt% solution of citric acid and brine. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified on silica gel by flash column chromatography (ISCO Companion D, 8Og column, 0-20% EtOAc/Petrol) to afford the title compound as a colourless solid (5.44 g, 87% yield).[00367 ] 1H NMR (DMSO-d6, 400 MHz) delta 2.32 (3H, s), 2.69 (3H, s), 3.28 (3H, s), 7.92 (IH, dd), 8.15 (IH, s); MS (ES+) 199.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1042986-00-4, 2-Fluoro-5-methylnicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/94992; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1042986-00-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1042986-00-4, name is 2-Fluoro-5-methylnicotinic acid. A new synthetic method of this compound is introduced below.

To a cooled to 0 C. mixture of 4-amino-benzoic acid methyl ester (0.930 g, 61.7 mmol) and 2-fluoro-5-methylnicotinic acid (10.0 g, 64.5 mmol) was added a solution of HOBt (10.0 g, 74.0 mmol) in dry DMF (100 mL). EDC (11.0 g, 70.9 mmol) was added and the reaction mass was stirred overnight at room temperature. The resulting mixture was poured into cold water (600 mL). The precipitated solid was collected by filtration, washed with water, and dried in vacuum to obtain methyl 4-(2-fluoro-5-methylnicotinamido)benzoate (14.2 g, 80%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1042986-00-4, 2-Fluoro-5-methylnicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; Enanta Pharmaceuticals, Inc.; Kim, In Jong; Panarese, Joseph; Blaisdell, Thomas P.; Yu, Jianming; Shook, Brian C.; Or, Yat Sun; US2019/2478; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem