Bandarage, Upul K. published the artcileDiscovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors, Product Details of C8H7NO, the publication is ACS Medicinal Chemistry Letters (2021), 12(1), 129-135, database is CAplus and MEDLINE.
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that control a wide variety of cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. PI3Kγ plays a critical role in mediating leukocyte chemotaxis as well as mast cell degranulation, making it a potentially interesting target for autoimmune and inflammatory diseases. We previously disclosed a novel series of PI3Kγ inhibitors derived from a benzothiazole core. The truncation of the benzothiazole core led to the discovery of a structurally diverse alkynyl thiazole series which displayed high PI3Kγ potency and subtype selectivity. Further medicinal chem. optimization of the alkynyl thiazole series led to identification of compounds such as 14 and 32, highly potent, subtype selective, and CNS penetrant PI3Kγ inhibitors. Compound 14 showed robust inhibition of PI3Kγ mediated neutrophil migration in vivo.
ACS Medicinal Chemistry Letters published new progress about 1060816-39-8. 1060816-39-8 belongs to pyridine-derivatives, auxiliary class Pyridines, name is 4-Ethynyl-2-methoxypyridine, and the molecular formula is C8H7NO, Product Details of C8H7NO.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem