Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072438-54-0, name is Methyl 2-(aminomethyl)pyridine-4-carboxylate hydrochloride. A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-(aminomethyl)pyridine-4-carboxylate hydrochloride
Take a 25 mL round bottom flask, Weigh4-carbomethoxy-2-pyridinemethylamine hydrochloride (1 g, 4.9 mmol) and potassium carbonate (1 g, 7.2 mmol) in 10 mL EtOAc. Stir at room temperature for 15 minutes; then a solution of 3-bromopropyne (0.29 g, 2.5 mmol) in 25 mL of acetonitrile was added dropwise to the mixture with a constant pressure dropping funnel. Stirring was continued at room temperature overnight (new points were generated by TLC detection).After the reaction is completed, the solvent is evaporated under reduced pressure. Add 50 mL of water to it, Extract three times with 35 mL of ethyl acetate each time. The organic phases were combined and washed with saturated brine. Dry with anhydrous sodium sulfate, After filtration, the mixture was steamed under reduced pressure. The column was wet-packed and eluted with ethyl acetate: petroleum ether: triethylamine = 25:74:1 to ethyl acetate: petroleum ether: triethylamine = 49:50:1.Yellow solid, yield 21%.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1072438-54-0, Methyl 2-(aminomethyl)pyridine-4-carboxylate hydrochloride.
Reference:
Patent; Shandong University; Jia Jihui; Zhan Peng; Liu Xinyong; Chen Chunyan; Jia Xiaxia; Zhang Shuo; Yu Ji; Wang Xueshun; (9 pag.)CN109369620; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem