Category: 1073182-59-8

Synthetic Route of 1073182-59-8 ,Some common heterocyclic compound, 1073182-59-8, molecular formula is C7H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirring suspension of methyl 5-amino-2-chloroisonicotinate (200 mg, 1.07 mmol) and 6-fluoro-2-naphthoic acid (245 mg, 1.29 mmol) in DCM (10.7 rriL) was added dropwise methanesulfonyl chloride (0.124 mL, 1.61 mmol). Hunigs base (0.560 rriL, 3.22 mmol) was then added, followed by DMAP (13.1 mg, 0.107 mmol) and the resulting solution was stirred at rt overnight. The solvent was evaporated in vacuo and the residue then re-suspended in DCM and ether. The precipitate was collected via vacuum filtration, washed with ether to furnish the desired material.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1073182-59-8, Methyl 5-amino-2-chloroisonicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INCEPTION 1, INC.; JACINTHO, Jason, Duarte; CLARK, Ryan, Christopher; SHENG, Tao; OBALLA, Renata, Marcella; STOCK, Nicholas, Simon; ROPPE, Jeffrey, Roger; (161 pag.)WO2017/192304; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1073182-59-8 , The common heterocyclic compound, 1073182-59-8, name is Methyl 5-amino-2-chloroisonicotinate, molecular formula is C7H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[00481] To a stirred solution of (5-amino-2-chloro-isonicotinic acid methyl ester (1.3 g, 7 mmol) in DCM (30 mL) was added Et3N (1.4 g, 14 mmol) and cyclopropanecarbonyl chloride (1.1 g, 10.5 mmol) at 0 C. The mixture was stirred at room temperature overnight. The mixture was evaporated in vacuum. The residue was diluted with water (50 mL). The aqueous phase was extracted with EA (80 mL x2). The extracts were washed with water, dried over anhydrous Na2S04 and filtered. The filtrate was evaporated in vacuum to residue, which was purified by silica gel chromatography (from PE to PE/EA = 10/1) to give (1.0 g, yield: 56 %) of 2-chloro-5-(cyclopropanecarbonyl-amino)-isonicotinic acid methyl ester as yellow solid. ‘H NMR (400MHZ, DMSO-i/6): delta = 10.56 (brs, 1H), 8.79 (s, 1H), 7.23 (s, 1H), 3.82 (s, 3H), 1.87- 1.80 (m, 3H), 0.94-0.83 (m, 4H).

The synthetic route of 1073182-59-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HEDRICK Michael P.; HERSHBERGER Paul M.; MALONEY Patrick R.; PEDDIBHOTLA Satyamaheshwar; PINKERTON Anthony B.; WO2015/200534; A2; (2015);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem