Related Products of 1092062-74-2 ,Some common heterocyclic compound, 1092062-74-2, molecular formula is C7H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of the product from strep a (0.200 g, 1.19 mmol, 1.0 mol. equiv.), 6- iodo- 1 -(tetrahydro-2//-pyran-2-yl)- 1 //-indazole (0.580 g, 1.79 mmol, 1.5 mol. equiv.), N,N- dimethylethylenediamine (0.040 mL, 0.36 mmol, 0.3 mol. equiv.) and K3PO4 (0.500 g, 2.38 mmol, 2.0 mol. equiv.) in dry DMF (4 mL) was purged with N2 for 5 minutes. Cul (0.034 g, (0404) 0.18 mmol, 2.0 mol. equiv.) was added and the reaction vial was further purged with N2 for 2 minutes, and then sealed. The reaction mixture was stirred overnight at 120 C. The reaction mixture was cooled and diluted with saturated aqueous NaHCCL solution (15 mL) and EtOAc (15 mL). The aqueous layer was separated and back extracted with additional EtOAc (15 mL). The organic layers were combined, washed with water (2 x 20 mL), brine (20 mL), and dried over MgS04. Concentration under reduced pressure and purification by column chromatography (S1O2, 0 to 80% gradient of CH2Cl2/EtOAc) furnished the title compound as a yellow solid (0.320 g, 0.870 mmol, 73%). ESI MS [M+H]+ for Ci9H8ClN50, calcd 368.1, found 368.0.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1092062-74-2, 6-Chloro-3-methyl-1H-pyrazolo[4,3-c]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARCUS BIOSCIENCES, INC.; BEATTY, Joel; DEBIEN, Laurent Pierre Paul; DREW, Samuel Lawrie; FOURNIER, Jeremy; GRANGE, Rebecca Louise; JACOB, Steven Donald; JEFFREY, Jenna Leigh; LAWSON, Kenneth V.; LELETI, Manmohan Reddy; LINDSEY, Erick Allen; MANDAL, Debashis; POWERS, Jay Patrick; TRAN, Anh Thu; THOMAS-TRAN, Rhiannon; YAN, Xuelei; (164 pag.)WO2020/46813; (2020); A1;,
Pyridine – Wikipedia,
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