Category: 1163693-01-3

A new synthetic route of 1163693-01-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1163693-01-3, 2-Chloro-3-iodo-4-methoxypyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1163693-01-3, name is 2-Chloro-3-iodo-4-methoxypyridine, molecular formula is C6H5ClINO, molecular weight is 269.47, as common compound, the synthetic route is as follows.Recommanded Product: 2-Chloro-3-iodo-4-methoxypyridine

A solution of 4a3 (33.1 g, 123 mmol), F (7.14 g, 123 mmol) and Cul (23.39 g, 123 mmol) in NMP (165 mL) is heated at 80 C. Methyl-2-chloro-2,2-difluoroacetate (51.8 mL, 491 mmol) is added and the mixture is heated 1.5 h at 120 C. The reaction mixture is poured into brine and Et20 is added. The solid is filtered and the layers separated. The organic layer is washed with water and the aqueous layer is extracted with Et20. The combined organic layers are washed with brine, dried over Na2S04, filtered and concentrated in vacuum followed by Kugelrohr distillation to afford the trifluoromethyl derivative 4a4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1163693-01-3, 2-Chloro-3-iodo-4-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; STAMMERS, Timothy; BARBEAU, Xavier; BEAULIEU, Pierre; BERTRAND-LAPERLE, Megan; BROCHU, Christian; EDWARDS, Paul, J.; FORGIONE, Pasquale; GODBOUT, Cedrickx; HUCKE, Oliver; JOLY, Marc-Andre; LANDRY, Serge; LEPAGE, Olivier; NAUD, Julie; PESANT, Marc; POIRIER, Martin; POIRIER, Maude; THAVONEKHAM, Bounkham; WO2011/32277; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 1163693-01-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1163693-01-3, 2-Chloro-3-iodo-4-methoxypyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1163693-01-3, name is 2-Chloro-3-iodo-4-methoxypyridine, molecular formula is C6H5ClINO, molecular weight is 269.47, as common compound, the synthetic route is as follows.Recommanded Product: 2-Chloro-3-iodo-4-methoxypyridine

A solution of 4a3 (33.1 g, 123 mmol), F (7.14 g, 123 mmol) and Cul (23.39 g, 123 mmol) in NMP (165 mL) is heated at 80 C. Methyl-2-chloro-2,2-difluoroacetate (51.8 mL, 491 mmol) is added and the mixture is heated 1.5 h at 120 C. The reaction mixture is poured into brine and Et20 is added. The solid is filtered and the layers separated. The organic layer is washed with water and the aqueous layer is extracted with Et20. The combined organic layers are washed with brine, dried over Na2S04, filtered and concentrated in vacuum followed by Kugelrohr distillation to afford the trifluoromethyl derivative 4a4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1163693-01-3, 2-Chloro-3-iodo-4-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; STAMMERS, Timothy; BARBEAU, Xavier; BEAULIEU, Pierre; BERTRAND-LAPERLE, Megan; BROCHU, Christian; EDWARDS, Paul, J.; FORGIONE, Pasquale; GODBOUT, Cedrickx; HUCKE, Oliver; JOLY, Marc-Andre; LANDRY, Serge; LEPAGE, Olivier; NAUD, Julie; PESANT, Marc; POIRIER, Martin; POIRIER, Maude; THAVONEKHAM, Bounkham; WO2011/32277; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem