Synthetic Route of 1186194-46-6 , The common heterocyclic compound, 1186194-46-6, name is 5-Bromo-6-methoxynicotinic acid, molecular formula is C7H6BrNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(5-bromopyridin-2-yl) ((2S) -2- (4-chlorophenyl) piperazin- 1 – yl) methanone hydrochloride(200 mg),5-Bromo-6-methoxynicotinic acid (130 mg),HATU (250 mg),Triethylamine (0.15 ml) and DMF (3 ml)Was stirred at room temperature for 2 hours.The mixture was extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane / ethyl acetate) and silica gel column chromatography (NH, hexane / ethyl acetate) to give the title compound (223 mg).
The synthetic route of 1186194-46-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MIZOJIRI, RYO; CARY, DOUGLAS ROBERT; HIRAYAMA, TAKAHARU; ITO, MASAHIRO; TANAKA, TOSHIO; IMAEDA, YASUHIRO; SASAKI, SHIGEKAZU; TAKAMI, KAZUAKI; FUKUDA, KOICHIRO; KAMAURA, MASAHIRO; MORISHITA, NAO; (133 pag.)JP2017/222626; (2017); A;,
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