Category: 1201187-18-9

Synthetic Route of 1201187-18-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1201187-18-9, name is 6-Chloro-4-(trifluoromethyl)nicotinonitrile. A new synthetic method of this compound is introduced below.

4-hydroxy was prepared in Reference Example 60 3- (piperidin-4-yl) -4- (trifluoromethyl) -1,4,5,7- tetrahydro -6H- pyrazolo [3,4-b] pyridin-6-one hydrochloride (150mg, 0.440mmol) in dimethyl sulfoxide (0.5 mL) solution of, N, N- diisopropylethylamine (89.8muL, 0.528mmol), and 6-fluoro-3- ( the compounds described in trifluoromethyl) pyridine-2-carbonitrile (US2008 / 275057 pamphlet, 136mg, 0.660mmol) was added, using a Biotage Inc. the Initiator (TM), 60 C., 20 min micro and the mixture was stirred while irradiating the waves.The reaction mixture was poured into water, and extracted twice with ethyl acetate, the resulting organic layer was washed successively with water and saturated brine, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure.The resulting residue was purified by silica gel column chromatography was purified in the elution solvent hexane / ethyl acetate = 88 / 12-0 / 10 gradient)], the title compound (43.1mg, yield: 21%) a.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1201187-18-9, 6-Chloro-4-(trifluoromethyl)nicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Daiichi Sankyo company limited; Sato, Rie; Kobayashi, Katsuhiro; Kaneko, Toshio; (188 pag.)JP2015/113323; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1201187-18-9, 6-Chloro-4-(trifluoromethyl)nicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Chloro-4-(trifluoromethyl)nicotinonitrile, blongs to pyridine-derivatives compound. Recommanded Product: 6-Chloro-4-(trifluoromethyl)nicotinonitrile

General procedure: To a stirred solution of 1Hpyrazole4carbaldehyde (1.00 g, 10.40 mmol) and 6bromo4methylnicotinonitrile (2.05 g, 10.40 mmol) in dioxane (15 mL) were added K2CO3 (4.31 g, 31.20 mmol). The resulting reaction mixture was degassed with nitrogen for 5 minutes then copper (I) iodide (0.59 g, 3.12 mmol) was added, followed by transN,N’dimethylcyclohexane1,2diamine (2.59 mL, 16.4 mmol). The resulting mixture was degassed again for 10 minutes and heated at 110 C for 1 h under microwave irradiation. The reaction mixture was cooled to ambient temperature, filtered through Celite and the organic layer was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep24 g, 2040% EtOAc/ nhexane) to obtain Intermediate 6 (1.15 g, 52.10%) as pale yellow solid. 1H NMR (300 MHz, DMSOd6) G^ppm 2.62 (s, 3 H), 8.10 (s, 1 H), 8.38 (s, 1 H), 8.95 (s, 1 H), 9.37 (s, 1 H), 9.98 (s, 1 H). LCMS (methodD), retention time 1.68 min, [M+H] 213.2.

The synthetic route of 1201187-18-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YADAV, Navnath Dnyanoba; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; GUNAGA, Prashantha; PANDA, Manoranjan; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (444 pag.)WO2018/222795; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem