In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120422-90-4, name is 4,6-Dichloro-3-methyl-1H-pyrazolo[4,3-c]pyridine, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives
A mixture of Intermediate 4 (33 mg, 0.163 mmol) and cyclohexylamine (19 muIota, 0.163 mmol) in n-butanol (1 ml) was stirred at rt overnight, monitoring the reaction by LC/MS. The mixture was heated to 100C overnight and more cyclohexylamine (57 muIota, 0.499 mmol) was added and stirring was continued at 100C overnight. The mixture was then diluted with ethyl acetate and washed with water and brine. The organic phase was dried and concentrated. The residue was purified by flash column chromatography on silica gel eluting with 2:1 petrol-ethyl acetate to give an off-white coloured solid (10 mg, 23%). 1H NMR (400 MHz, DMSO-d6) delta ppm 1.13 – 1.25 (m, 1 H), 1.28 – 1.47 (m, 4 H), 1.58 – 1.66 (m, 1 H), 1.69 – 1.79 (m, 2 H), 1.90 – 1.97 (m, 2 H), 2.56 (s, 3 H), 3.91 – 4.01 (m, 1 H), 5.85 (d, J=7.8 Hz, 1 H), 6.56 (s, 1 H). m/z (ES+APCI)+ : 265/267 [M+H]+
The synthetic route of 120422-90-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; CHAN, Brayn; ESTRADA, Anthony; SWEENEY, Zachary; MCIVER, Edward Giles; WO2011/141756; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem