Electric Literature of 1211540-74-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1211540-74-7, name is Ethyl 2-(5-bromo-3-nitropyridin-2-yl)acetate, molecular formula is C9H9BrN2O4, molecular weight is 289.08, as common compound, the synthetic route is as follows.
To a solution of Intermediate 88 (10.0 g, 34.6 mmol) in acetic acid (200 mL) wasadded iron (9 .51 g, 173 mmol). The reaction mixture was stirred at 60C for 4 h, then10 diluted with EtOAc (200 mL ), stirred for 15 minutes, filtered through a pad of Celite, andwashed with EtOAc (3 x 200 mL). The organic layer was separated, dried overanhydrous NazS04 and concentrated in vacuo. The crude residue was dissolved in 5%MeOH in EtOAc (30 mL) and adsorbed onto Fluorosil. The resulting slurry was filteredthrough a Celite pad and washed with 5% MeOH in EtOAc (3 x 200 mL). The organic15 layer was dried over anhydrous NazS04 and concentrated in vacuo, to afford the titlecompound (5.00 g, 68%) as a brown solid. DH (400 MHz, DMSO-d6) 3.57 (s, 2H), 7.30(s, IH), 8.17 (s, IH), 10.67 (br s, IH). HPLC-MS (method 6): MH+ m/z 213.0, RT 1.31minutes.
Statistics shows that 1211540-74-7 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(5-bromo-3-nitropyridin-2-yl)acetate.
Reference:
Patent; UCB BIOPHARMA SPRL; BRACE, Gareth Neil; CHAPPELL, Rose Elizabeth; DEBOVES, Herve Jean Claude; FOLEY, Anne Marie; FOULKES, Gregory; JONES, Elizabeth Pearl; LECOMTE, Fabien Claude; QUINCEY, Joanna Rachel; SCHULZE, Monika-Sarah Elisabeth Dorothea; SELBY, Matthew Duncan; SMALLEY, Adam Peter; TAYLOR, Richard David; TOWNSEND, Robert James; ZHU, Zhaoning; (278 pag.)WO2018/229079; (2018); A1;,
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