Adding a certain compound to certain chemical reactions, such as: 1214323-40-6, 5-Chloro-2-(difluoromethoxy)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1214323-40-6, blongs to pyridine-derivatives compound. Product Details of 1214323-40-6
A stirred mixture of 5-chloro-2-(difluoromethoxy)pyridine (0.13 g, 0.75 mmol), bis(pinacolato)diboron (0.21 g, 0.83 mmol), [l,l-bis(diphenylphosphino)- ferrocene]palladium(II) chloride, complex with DCM (62 mg, 0.076 mmol), and potassium acetate (0.23 g, 2.3 mmol) in dry 1,4-dioxane (4 mL) was purged three times with argon and placed under vacuum three times. The mixture was heated to 90 C and monitored with LC-MS and TLC. After 21 h, the reaction was cooled to rt then filtered through Celite. The organic solvent was removed under reduced pressure, and the black residue was identified as (6-(difluoro- methoxy)pyridin-3-yl)boronic acid, used without purification.
The synthetic route of 1214323-40-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; DRANSFIELD, Paul, John; GONZALEZ LOPEZ DE TURISO, Felix; KOHN, Todd, J.; PATTAROPONG, Vatee; SIMARD, Jillian, L.; WO2012/3283; (2012); A1;,
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