Electric Literature of 1214377-45-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1214377-45-3, name is 2-Chloro-6-(difluoromethoxy)pyridine, molecular formula is C6H4ClF2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
At room temperature, 2-chloro-6- (difluoromethoxy) pyridine (40.00g, 222.78mmol),Trifluoroacetic anhydride (120ml), fuming nitric acid (16.00g, 229.46mmol) was added dropwise at 0 C, and the reaction was performed at 0-10 C for 2h.Add ice water (1000 ml), extract with methyl tertiary ether (300 ml x 3), combine the organic phases, concentrate,Column chromatography gave 25.00 g of a pale yellow solid with a yield of 50%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1214377-45-3, 2-Chloro-6-(difluoromethoxy)pyridine.
Reference:
Patent; Jiangsu Weikaier Pharmaceutical Technology Co., Ltd.; Gong Yanchun; Meng Lei; Guo Qirun; Liu Yongqiang; (65 pag.)CN110642838; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem