Category: 1219095-87-0

Adding a certain compound to certain chemical reactions, such as: 1219095-87-0, tert-Butyl (2-methylpyridin-3-yl)carbamate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1219095-87-0, blongs to pyridine-derivatives compound. Recommanded Product: 1219095-87-0

Tert-butyl N-(2-methylpyridin-3-yl)carbamate (5.41 g, 25.99 mmol) was dissolved in AcOH (100 mL). PtO2 (2.7 g) was added and the mixture was stirred overnight under H2 atmosphere (4 atm). The catalyst was filtered off, the solvent was evaporated and the residue neutralized with K2CO3 solid. The mixture was extracted with ethyl acetate (3×250 mL) and DCM (3×100 mL). The combined organic phases was concentrated under reduced pressure to give tert-butyl N-(2- methylpiperidin-3-yl)carbamate (7.0 g, quant. yield) as diastereoisomeric mixture. The diastereoisomeric mixture was purified by preparative chiral HPLC to give: tert-butyl N-[(2S,3S)-2-methylpiperidin-3-yl]carbamate (1.94 g, 9.05 mmol), tert-butyl N- [(2R,3R)-2-methylpiperidin-3-yl]carbamate (1.39 g, 6.48 mmol).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1219095-87-0, its application will become more common.

Reference:
Patent; PHARMACYCLICS LLC.; ATALLAH, Gordana, Babic; CHEN, Wei; JIA, Zhaozhong, J.; POZZAN, Alfonso; RAVEGLIA, Lucal, Francesco; ZANALETTI, Riccardo; (815 pag.)WO2016/196776; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1219095-87-0, tert-Butyl (2-methylpyridin-3-yl)carbamate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1219095-87-0, blongs to pyridine-derivatives compound. Recommanded Product: 1219095-87-0

Tert-butyl N-(2-methylpyridin-3-yl)carbamate (5.41 g, 25.99 mmol) was dissolved in AcOH (100 mL). PtO2 (2.7 g) was added and the mixture was stirred overnight under H2 atmosphere (4 atm). The catalyst was filtered off, the solvent was evaporated and the residue neutralized with K2CO3 solid. The mixture was extracted with ethyl acetate (3×250 mL) and DCM (3×100 mL). The combined organic phases was concentrated under reduced pressure to give tert-butyl N-(2- methylpiperidin-3-yl)carbamate (7.0 g, quant. yield) as diastereoisomeric mixture. The diastereoisomeric mixture was purified by preparative chiral HPLC to give: tert-butyl N-[(2S,3S)-2-methylpiperidin-3-yl]carbamate (1.94 g, 9.05 mmol), tert-butyl N- [(2R,3R)-2-methylpiperidin-3-yl]carbamate (1.39 g, 6.48 mmol).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1219095-87-0, its application will become more common.

Reference:
Patent; PHARMACYCLICS LLC.; ATALLAH, Gordana, Babic; CHEN, Wei; JIA, Zhaozhong, J.; POZZAN, Alfonso; RAVEGLIA, Lucal, Francesco; ZANALETTI, Riccardo; (815 pag.)WO2016/196776; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem