Category: 122475-57-4

Adding a certain compound to certain chemical reactions, such as: 122475-57-4, 4-Amino-2,3-dimethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H10N2, blongs to pyridine-derivatives compound. Computed Properties of C7H10N2

To a solution of diphosgene (182 mg; 0.90 mmol) in THF (4 mL) was added dropwise a solution of 4- amino-2,3-dimethylpyridine (187 mg; 1.50 mmol), DMAP (19 mg; 0.15 mmol) and TEA (0.43 mL; 3.00 mmol) in THF (4mL) at 0 C. The mixture was allowed to warm up to rt and stirred for 2 h. The mixture was then treated with a solution of 4-[(4-chloro-2-fluoro-phenyl)methylene]piperidine, hydrochloride (390 mg; 1.50 mmol) and TEA (0.43 mL; 3.00 mmol) in THF (4 mL). After stirring for 16 h, the mixture was concentrated to dryness. The residue was purified by preparative HPLC to afford 4-[(4-chloro-2- fluoro-phenyl)methylene] -A-(2,3 -dimethyl-4-pyridyl)piperidine- 1 -carboxamide, trifluoroacetic acid (120 mg) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,122475-57-4, 4-Amino-2,3-dimethylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; BASILEA PHARMACEUTICA INTERNATIONAL AG; RICHALET, Florian; EL SHEMERLY, Mahmoud; LANE, Heidi; (43 pag.)WO2019/115709; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 122475-57-4, 4-Amino-2,3-dimethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H10N2, blongs to pyridine-derivatives compound. Computed Properties of C7H10N2

To a solution of diphosgene (182 mg; 0.90 mmol) in THF (4 mL) was added dropwise a solution of 4- amino-2,3-dimethylpyridine (187 mg; 1.50 mmol), DMAP (19 mg; 0.15 mmol) and TEA (0.43 mL; 3.00 mmol) in THF (4mL) at 0 C. The mixture was allowed to warm up to rt and stirred for 2 h. The mixture was then treated with a solution of 4-[(4-chloro-2-fluoro-phenyl)methylene]piperidine, hydrochloride (390 mg; 1.50 mmol) and TEA (0.43 mL; 3.00 mmol) in THF (4 mL). After stirring for 16 h, the mixture was concentrated to dryness. The residue was purified by preparative HPLC to afford 4-[(4-chloro-2- fluoro-phenyl)methylene] -A-(2,3 -dimethyl-4-pyridyl)piperidine- 1 -carboxamide, trifluoroacetic acid (120 mg) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,122475-57-4, 4-Amino-2,3-dimethylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; BASILEA PHARMACEUTICA INTERNATIONAL AG; RICHALET, Florian; EL SHEMERLY, Mahmoud; LANE, Heidi; (43 pag.)WO2019/115709; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem