Category: 129768-95-2

Adding a certain compound to certain chemical reactions, such as: 129768-95-2, (4-Methylpyridin-2-yl)methanamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H10N2, blongs to pyridine-derivatives compound. HPLC of Formula: C7H10N2

4-methyl-2-(pyrrolidin-2-one-1-yl)methyl pyridine g 3.66 (0.03 moles) of 4-methyl-2-aminomethyl pyridine were dissolved in 60 ml of dry CHCl3, ml 16.8 of triethylamine were added and the resulting solution was cooled at -20 C. g 4 (0.036 moles) of 4-chlorobutyrroylchloride were then dropped in, on stirring and cooling, at such a rate to keep the temperature at -20 C. The reaction was completed by stirring at room temperature for 2 hours, TLC CHCl3 /MeOH/NH3; 94.5/5/0.5. The reaction mixture was poured in 40 ml of 20% Na2 CO3; the organic layer was separated and the aqueous layer was extracted twice with CH2 Cl2. The collected organic phases were dried on Na2 SO4, filtered and evaporated i.v. The crude oil obtained was dissolved in 300 ml THF dry and under nitrogen atmosphere, at 0 C., g 1.3 of NaH 80% and ml 1 of HMPT were added.

The synthetic route of 129768-95-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dr. L. Zambeletti SpA; US5089507; (1992); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 129768-95-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 129768-95-2, name is (4-Methylpyridin-2-yl)methanamine. A new synthetic method of this compound is introduced below.

4-methyl-2-(pyrrolidin-2-one-1-yl)methyl pyridine g 3.66 (0.03 moles) of 4-methyl-2-aminomethyl pyridine were dissolved in 60 ml of dry CHCl3, ml 16.8 of triethylamine were added and the resulting solution was cooled at -20C. g 4 (0.036 moles) of 4-chlorobutyrroylchloride were then dropped in, on stirring and cooling, at such a rate to keep the temperature at -20C. The reaction was completed by stirring at room temperature for 2 hours, TLC CHCl3/MeOH/NH3; 94.5/5/0.5. The reaction mixture was poured in 40 ml of 20% Na2CO3; the organic layer was separated and the aqueous layer was extracted twice with CH2Cl2. The collected organic phases were dried on Na2SO4, filtered and evaporated i.v. The crude oil obtained was dissolved in 300 ml THF dry and under nitrogen atmosphere, at 0C, g 1.3 of NaH 80% and ml 1 of HMPT were added.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,129768-95-2, (4-Methylpyridin-2-yl)methanamine, and friends who are interested can also refer to it.

Reference:
Patent; Smithkline Beecham Farmaceutici S.p.A.; EP447704; (1991); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem